In spite of being a minor cellular subset, cancer stem cells (CSCs) fundamentally contribute to intra-tumor heterogeneity. With the biological features of self-renewal and differentiation, CSCs confer a driving force for malignant recurrence and anti-cancer drug resistance in oncologic patients, which highlight an unmet clinical need calling for innovative medicine to Come up.
Due to the elusiveness of specific biomarkers and biological regulation for CSCs, a number of precisely targeted therapeutic approaches against CSCs are at their infancy far from reaching the clinic. However, we have herein been able to sort out three groups of CSC inhibitors which are clinically available, and proposed to take the advantages of these drugs to improve the therapeutic efficacy of existing anti-cancer treatments.
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